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KMID : 0357920020360050338
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Korean Journal of Pathology
2002 Volume.36 No. 5 p.338 ~ p.340
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Partial Trisomy 13 (Patau Syndrome): An Autopsy Report
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Choi Kyung-Chan
Shin Hyung-Sik
Park Young-Euy
Seo Jung-Lae
Lee Sung-Won
Ro Eu-Sun
Kim Yong-Pil
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Abstract
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Trisomy 13 (Patau syndrome) is rare and usually fatal if contracted within the first six months of life. We report a case of a male fetus with the typical features of Patau syndrome. He was terminated in a 27-year-old mother at the gestational age of 32+4 weeks. In chromsomal analysis by GTG banding technique, the karyotype of the fetus was 46,XY,rec(13) dup(13q)inv(13)(p13q21.3)(=partial trisomy 13q); and his mother´s karyotype was 46,XX, inv(13)(p13q21.3)(=pericentric inversion). His father had normal karyotype, 46,XY. Ultrasonography showed fluid-nature content, which was occupying the entire intracranium, but preserving the brain stem and cerebellum. Postmortem examination disclosed holoprosencephaly, hydrocephalus, a single nostril, bilateral anophthalmia, ventricular septal defect, and a single umbilical artery.
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KEYWORD
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Autopsy, Trisomy, Holoprosencephaly, Karyotyping
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